Investigation of the transformations of a novel anti-cancer agent combining HPLC, HPLC–MS and direct ESI–HRMS analyses
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چکیده
منابع مشابه
Investigation of the transformations of a novel anti-cancer agent combining HPLC, HPLC–MS and direct ESI–HRMS analyses
One of the main problems of anti-cancer therapy is an insufficient differentiation between normal and malignant cells by the known anti-proliferant agents. The antibody-directed enzyme prodrug therapy is a promising approach for a selective treatment of cancer, in which a non-toxic prodrug is enzymatically converted into a highly cytotoxic drug at the surface of malignant cells by a targeted an...
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ژورنال
عنوان ژورنال: Analytical and Bioanalytical Chemistry
سال: 2009
ISSN: 1618-2642,1618-2650
DOI: 10.1007/s00216-009-2963-x